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Artificial sweeteners: what they don’t tell you

Artificial Sweeteners: What They Don’t Tell You
The advertising you see on television and other media about sweeteners is driven by commercial marketing purposes, not by a concern for consumer health. Here’s what research says about the most common sweeteners:
- Animal research has shown that all artificial sweeteners currently approved and considered safe by the U.S. Food and Drug Administration and the relevant authorities in Europe cause DNA damage and interfere with the normal and healthy activity of intestinal bacteria.
- The artificial sweeteners analyzed in the study presented here are aspartame, sucralose, saccharin, neotame, advantame, and potassium acesulfame, also known as acesulfame-K.
- Saccharin caused the most severe and extensive damage, exhibiting both cytotoxic and genotoxic effects, meaning it is toxic to cells and damages the genetic information within them (which can cause mutations).
- Aspartame and potassium acesulfame were found to cause DNA damage. Additionally, neotame was found to cause metabolic disorders and elevated concentrations of various fatty acids, as well as lipids and cholesterol.
- Another recent study has shown that artificial sweeteners damage vascular function and cause cellular changes that may be significant during the onset and progression of diabetes and obesity.
The animal study,1,2,3,4,5 published in the journal Molecules, found that all artificial sweeteners currently approved and considered safe by the U.S. Food and Drug Administration cause DNA damage and interfere with the normal and healthy activity of intestinal bacteria.
Some of the artificial sweeteners included in this study and their results are:
- Saccharin caused the most severe and extensive damage, exhibiting both cytotoxic and genotoxic effects, meaning it is toxic to cells and damages the genetic information within them (which can cause mutations).
- Sucralose caused: Destruction of intestinal bacteria. Alteration of glucose, insulin, which could elevate the risk of diabetes. Fewer red blood cells. Increased male infertility. At higher doses, it causes brain injuries. Calcified and enlarged kidneys. Risk of spontaneous abortions. Possible interactions with medications.
- It was found that neotame caused a metabolic disturbance in mice and elevated concentrations of various fatty acids, as well as lipids and cholesterol. Additionally, various genes decreased due to this sweetener.
- It was discovered that aspartame and potassium acesulfame – the latter is commonly found in sports supplements – cause DNA damage.
Artificial Sweeteners Are Linked to Weight Gain and Health Problems
Research published over the last three decades has also convincingly demonstrated that artificial sweeteners stimulate appetite, increase carbohydrate cravings, and produce various metabolic dysfunctions that promote fat storage and weight gain.
In 1986, a study17 that examined nearly 78,700 women over one year found that those who used artificial sweeteners were significantly more likely to gain weight compared to those who did not, regardless of their initial weight.
According to the researchers, the results “could not be explained by differences in dietary consumption patterns. The data do not support the hypothesis that long-term use of artificial sweeteners may help with weight loss or prevent weight gain.”
In 2010, a significant scientific review19 published in the Yale Journal of Biology and Medicine summarized the epidemiological and experimental evidence available on the effects of artificial sweeteners on weight and explained these effects in terms of the neurobiology related to the food reward system.
Considering what we now know about the gut microbiome and its influence on health and disease, it is increasingly easy to glimpse how and why artificial sweeteners can wreak havoc on your health.
The vast majority of packaged products contain one or more of these sweeteners in their composition. Keep this in mind.
Substitutes for Artificial Sweeteners
Two of the best substitutes for sugar are from the plant kingdom: Stevia and Lo Han Guo (also spelled as Luo Han Kuo). Stevia, a very sweet herb derived from the South American stevia plant, is sold as a supplement. It is completely safe in its natural form and can be used to sweeten most foods and beverages.
A third alternative is the use of pure glucose. You can buy pure glucose (dextrose). Unlike fructose, glucose can be used directly by every cell in your body and is a much safer alternative.
Sources and References of the Studies
- 1Molecules 2018; 23(10): 2454
- 2,6 Business Insider October 2, 2018
- 3US News October 1, 2018
- 4Inverse October 1, 2018
- 5Science Daily October 1, 2018
- 7Journal of Toxicology and Environmental Health, Part B: Critical Reviews, 16:7, 399-451
- 8,9, 12 J Toxicol Environ Health A. 2008;71(21):1415-29
- 10Diabetes Care. 2013 Sep;36(9):2530-5.
- 11Food Chem Toxicol. 2000;38 Suppl 2:S31-41
- 13Experimental Biology Conference Publication # A322 603.20
- 14US News April 23, 2018
- 15Medical News Today April 23, 2018
- 16Gizmodo April 22, 2018
- 17Preventive Medicine 1986 Mar;15(2):195-202
- 18San Antonio Heart Study June 14, 2005
- 19Yale Journal of Biology and Medicine 2010 June; 83(2): 101–108
- 20Trends in Endocrinology & Metabolism 2013 Sep;24(9):431-41
- 21com July 10, 2013
- 22The Journal of Physiology 2013 Nov 15;591(22):5727-44
- 23Scientific American September 5, 2013
- 24Nature October 2014; 514: 181-186

